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Correlation Between Advanced Glycation End‐Products, Lower Urinary Tract Symptoms and Bladder Dysfunctions in Patients with type 2 Diabetes Mellitus
Author(s) -
GALÌ Alessandro,
MUCCIARDI Giuseppe,
BUTTICÈ Salvatore,
SUBBA Enrica,
D'AMICO Carmela,
LEMBO Francesco,
MAGNO Carlo
Publication year - 2017
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/luts.12102
Subject(s) - medicine , lower urinary tract symptoms , contractility , urology , urinary system , diabetes mellitus , urinary bladder , cystometry , detrusor muscle , endocrinology , prostate , cancer
Objectives To explore whether serum and urinary a dvanced g lycation e nd‐products ( AGEs ) are related to urinary symptoms and bladder dysfunctions in diabetic patients. Methods Forty‐seven patients with type 2 D iabetes mellitus ( T2DM ) and lower urinary tract symptoms ( LUTS ) were enrolled. LUTS evaluation was performed by IPSS ( I nternational P rostatic S ymptoms S core), QoL ( q uality of life), OAB ( o veractive b ladder). ICI‐SF ( I nternational C onsultation on I ncontinence – short form) quaestionneires; ultrasound examination, evaluation of postvoid residual ( PVR ), uroflowmetry, cystometry with pressure‐flow study ( PFS ) were performed to detect bladder dysfunctions. Serum and urinary AGEs were quantified by ELISA method. Results Patients were divided into four subgroups: (i) normal‐detrusor‐contractility + normal‐ detrusor‐activity (1 ♂ [4.8%] and 4 ♀ [21%]), (ii) impaired‐detrusor‐contractility + normal‐detrusor‐ activity (4 ♂ [19.1%] and 0 ♀), (iii) normal‐detrusor‐contractility + detrusor‐overactivity (1 ♂ [4.8%] and 6 ♀ [31.6%]), (iv) impaired‐detrusor‐contractility + detrusor‐overactivity (15 ♂ [71.4%] and 9 ♀ [47.4%]). Serum AGEs were 12.2 ± 5.5 in men and 10.4 ± 5.6 in women; urinary AGEs were 1.5 ± 1.1 in men and 2.5 ± 1.6 in women. Serum AGEs exhibited a positive correlation with IPSS ( P < 0.05) and OAB ‐q scores ( P < 0.01). Increased serum AGEs were associated with a significant reduction in the parameters reflecting impaired detrusor contractility with simultaneous reductions of urinary AGEs ( P < 0.01). A greater correlation was observed between serum AGEs and subgroup 4 ( P < 0.05). Conclusions Serum AGEs seem to be early markers of diabetic complications and appear to be related to LUTS and bladder dysfunctions.