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Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug‐Induced Liver Injury in the Spanish DILI Registry
Author(s) -
SanabriaCabrera Judith,
SanjuánJiménez Rocío,
Clavijo Encarnación,
MedinaCáliz Inmaculada,
GonzálezJiménez Andrés,
GarcíaCortés Miren,
OrtegaAlonso Aida,
JiménezPérez Miguel,
GonzálezGrande Rocío,
Stephens Camilla,
RoblesDíaz Mercedes,
Lucena M Isabel,
Andrade Raúl J.
Publication year - 2021
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.14713
Subject(s) - medicine , seroprevalence , hepatitis e virus , incidence (geometry) , hepatitis e , hepatitis , gastroenterology , liver injury , antibody , immunology , serology , genotype , biology , biochemistry , physics , optics , gene
Abstract Background and Aims Drug‐induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis assessment in Spain. The aims of this study were to establish the role of HEV infection and its phenotypic presentation in patients initially suspected of DILI and to determine the anti‐HEV seroprevalence rate. Methods An analysis of 265 patients with suspected DILI and considered for enrolment in the Spanish DILI Registry and 108 controls with normal liver profiles was undertaken. Anti‐HEV Immunoglobulin (Ig) G antibodies were analysed in serum from all subjects. In those with serum samples extracted within 6 months from liver damage onset (n = 144), HEV antigen (Ag) and anti‐HEV IgM antibodies were tested in duplicate by ELISA. In addition, RT‐PCR was performed externally in eight patients. Results Out of 144 patients, 12 (8%) were positive for anti‐HEV IgM, mean age was 61 years. Underlying hepatic diseases (OR = 23.4, P < .001) and AST peak >20 fold upper limit of normal (OR = 10.9, P = .002) were associated with the diagnosis of acute hepatitis E. The overall anti‐HEV IgG seroprevalence rate was 35%, evenly distributed between patients with suspected DILI (34%), and controls (39%). Conclusions HEV seroprevalence and acute hepatitis E rates are relatively high in Spain. A search for active HEV infection is therefore advised in patients assessed for suspicion of DILI, particularly in patients with underlying liver diseases and high transaminase levels.