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Association between consumption of edible seaweeds and newly diagnosed non‐alcohol fatty liver disease: The TCLSIH Cohort Study
Author(s) -
Li Huiping,
Gu Yeqing,
Wu Xiaohui,
Rayamajhi Sabina,
Bian Shanshan,
Zhang Qing,
Meng Ge,
Liu Li,
Wu Hongmei,
Zhang Shunming,
Wang Yawen,
Zhang Tingjing,
Wang Xuena,
Thapa Amrish,
Sun Shaomei,
Wang Xing,
Jia Qiyu,
Song Kun,
Niu Kaijun
Publication year - 2021
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.14655
Subject(s) - medicine , fatty liver , odds ratio , quartile , confidence interval , obesity , population , logistic regression , nonalcoholic fatty liver disease , disease , gastroenterology , environmental health
Background & aims Seaweeds are rich sources of anti‐oxidants and anti‐inflammatory properties, which are beneficial to non‐alcoholic fatty liver disease (NAFLD). However, whether seaweed consumption is associated with NAFLD is unknown. We investigated the association of seaweed consumption with newly diagnosed NAFLD in a large‐scale adult population. Methods This cross‐sectional study involved 24 572 participants aged over 18 years. NAFLD was diagnosed by results of liver ultrasonography and alcohol intake. Dietary information was assessed using a validated and standardized 100‐item food frequency questionnaire. Multivariate logistic analysis was used to evaluate the association between seaweed consumption and NAFLD. Results The prevalence of newly diagnosed NAFLD was 20.1%. After adjustment for sociodemographic characteristics, lifestyle factors, and other dietary intakes, the multivariable adjusted odds ratios (95% confidence intervals) of newly diagnosed NAFLD across seaweed consumption were 1.00 (reference) for almost never, 1.03 (0.93, 1.15) for <1 time/wk, 1.01 (0.90, 1.13) for 1 time/wk, and 0.84 (0.73, 0.96) for >1 times/wk ( P for trend < .001). Stratified analyses suggested a potential effect modification by obesity status; the odds ratios (95% confidence intervals) across extreme quartiles was 0.77 (0.66, 0.91) in non‐obese participants and 1.02 (0.79, 1.33) in obese participants ( P for interaction < .001). Conclusion Seaweed consumption is negatively associated with NAFLD, especially in non‐obese participants.