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Comparison of the prognostic value of inflammation‐based scores in early recurrent hepatocellular carcinoma after hepatectomy
Author(s) -
Wang Chenwei,
He Wei,
Yuan Yichuan,
Zhang Yuanping,
Li Kai,
Zou Ruhai,
Liao Yadi,
Liu Wenwu,
Yang Zhiwen,
Zuo Dinglan,
Qiu Jiliang,
Zheng Yun,
Li Binkui,
Yuan Yunfei
Publication year - 2020
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.14281
Subject(s) - medicine , hazard ratio , receiver operating characteristic , hepatocellular carcinoma , proportional hazards model , neutrophil to lymphocyte ratio , confidence interval , multivariate analysis , gastroenterology , inflammation , hepatectomy , lymphocyte , oncology , surgery , resection
Background & Aims Inflammation‐based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Index (PI), Prognostic Nutritional Index (PNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and systemic immune‐inflammation index (SII), are correlated with the survival of hepatocellular carcinoma (HCC) patients, while remain unclear for recurrent HCC. This study aimed to compare the prognostic value of inflammation‐based prognostic scores for post‐recurrence survival (PRS) in patients with early recurrent HCC (ErHCC, within 2 years after hepatectomy). Methods A total of 580 patients with ErHCC were enrolled retrospectively. The association between the independent baseline and the time‐dependent variables and PRS was evaluated by cox regression. The prediction accuracy of the inflammation‐based prognostic scores was assessed by time‐dependent receiver operating characteristic (ROC) and Harrell's concordance index (C‐index) analyses. Results The GPS, mGPS, PI, PNI, NLR, PLR, LMR and SII were all related to the PRS of ErHCC patients, while only the SII ( P < .001) remained an independent predictor for PRS in multivariate analysis (hazard ratio: 1.92, 95% confidence interval: 1.33‐2.79). Both the C‐index of the SII (0.65) and the areas under the ROC curves showed that the SII score was superior to the other inflammation‐based prognostic scores for predicting the PRS of ErHCC patients. Conclusions The SII is a useful prognostic indicator for PRS in patients with ErHCC after hepatectomy and is superior to the other inflammation‐based prognostic scores in terms of prognostic ability.