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Long‐term safety and efficacy of nucleo(t)side analogue therapy in hepatitis B
Author(s) -
Buti Maria,
RiveiroBarciela Mar,
Esteban Rafael
Publication year - 2018
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13641
Subject(s) - entecavir , tenofovir alafenamide , medicine , tenofovir , chronic hepatitis , hepatitis b , virology , pharmacology , viral load , human immunodeficiency virus (hiv) , antiretroviral therapy , lamivudine , virus
Long‐term treatment of chronic hepatitis B ( CHB ) with nucleos(t)ide analogues is often necessary to achieve durable viral suppression. Therefore, current guidelines recommend the most potent drugs with optimal resistance profiles. Entecavir ( ETV ), tenofovir disoproxil fumarate ( TDF ) and tenofovir alafenamide ( TAF ) are the first‐line monotherapies for CHB . All of these drugs are highly effective in suppressing viral replication but with slightly different safety profiles. This review provides an overview of the long‐term efficacy and safety data that have become available over the 10 years since ETV and TDF were first approved for the treatment of chronic hepatitis, and recent data on TAF in patients with CHB .