Premium
Clinical implications of controlled attenuation parameter in a health check‐up cohort
Author(s) -
Kwak MinSun,
Chung Goh Eun,
Yang Jong In,
Yim Jeong Yoon,
Chung Su Jin,
Jung Se Young,
Kim Joo Sung
Publication year - 2018
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13558
Subject(s) - medicine , fatty liver , body mass index , odds ratio , gastroenterology , metabolic syndrome , nonalcoholic fatty liver disease , steatosis , triglyceride , alanine transaminase , confidence interval , uric acid , population , waist , endocrinology , disease , cholesterol , obesity , environmental health
Background & Aims Evaluation of the controlled attenuation parameter ( CAP ) is a promising noninvasive method for assessing hepatic steatosis. Despite the increasing reliability of the CAP for assessing steatosis in subjects with chronic liver disease, few studies have evaluated the CAP in asymptomatic subjects without overt liver disease. Therefore, we aimed to evaluate the usefulness of the CAP for a health check‐up population. Methods We enrolled subjects who underwent abdominal ultrasonography ( US ), FibroScan (Echosens, France) and blood sampling during medical health check‐ups. The CAP was measured using FibroScan, and increased CAP was defined as CAP ≥ 222 dB /m. Results A total of 1133 subjects were included; 589 subjects (52.0%) had fatty liver based on US , and 604 subjects (53.3%) had increased CAP . Increased CAP was significantly associated with metabolic abnormalities, including higher body mass index ( BMI )[odds ratio ( OR ) = 1.33;95% confidence interval ( CI ),1.24‐1.43; P < .001], higher alanine aminotransferase ( ALT ) ( OR = 1.02; 95% CI , 1.01‐1.04; P = .003), higher insulin ( OR = 1.04; 95% CI , 1.00‐1.08; P = .037), higher triglyceride (OR = 1.00; 95% CI, 1.00‐1.01; P = 0.042) and older age ( OR = 1.02; 95% CI , 1.00‐1.03; P = .05). Furthermore, a comparison of clinical parameters among three groups (normal vs no fatty liver by US but increased CAP vs fatty liver based on US ) revealed that metabolic parameters, including blood pressure, BMI , waist circumference, aspartate aminotransferase ( AST ), ALT , triglycerides, fasting glucose, uric acid, insulin, homeostasis model assessment‐estimated insulin resistance and liver stiffness measurements, gradually increased across the three groups (all P < .001). Conclusions In conclusion, increased CAP could be an early indicator of fatty liver disease with metabolic abnormalities that manifests even before a sonographic fatty change appears.