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Ultra‐short bowel is an independent risk factor for liver fibrosis in adults with home parenteral nutrition
Author(s) -
CazalsHatem Dominique,
Billiauws Lore,
Rautou PierreEmmanuel,
Bondjemah Vanessa,
Poté Nicolas,
Corcos Olivier,
Paradis Valérie,
Joly Francisca
Publication year - 2018
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13545
Subject(s) - medicine , gastroenterology , parenteral nutrition , fibrosis , short bowel syndrome , liver biopsy , risk factor , steatohepatitis , cholestasis , sepsis , fatty liver , biopsy , disease
Abstract Background & Aims Intestinal failure‐associated liver disease is rare in adults and risk factors are unclear. The aim of this study was to determine risk factors of liver fibrosis in adults receiving home parenteral nutrition for intestinal failure and its impact on survival. Methods We retrospectively analysed patients with irreversible intestinal failure who underwent a liver biopsy between 2000 and 2013. Significant liver fibrosis was defined as ≥F2 according to NASH ‐ CRN score. Results Thirty‐two patients (46 years [29‐60]) underwent liver biopsy 55 months (9‐201) after beginning parenteral nutrition. Twenty‐six patients (81%) had a short bowel (gut < 200 cm), including 12 (37%) with an ultra‐short bowel (gut < 20 cm). Eighteen patients (56%) had liver fibrosis (4 F2, 10 F3, 4 F4), associated with steatohepatitis (72%) and/or cholestasis (17%). Factors associated with occurrence of liver fibrosis included ultra‐short bowel (83% vs 13% at 60 months; P < .001), alcohol consumption (73% vs 33% at 60 months; P < .001) and diabetes (80% vs 34% at 60 months; P = .01). Home parenteral nutrition composition, quantity, or duration, episodes of sepsis, abandoned bowel segment were not associated with fibrosis. Ultra‐short bowel [risk ratio 12.4, P < .001] and alcohol consumption [risk ratio 7.4, P = .009] independently predicted the development of liver fibrosis on multivariate analysis. After a median follow‐up of 118 months (72‐155), survival was poorer in patients who developed liver fibrosis than in those without (59% vs 92% at 120 months; P = .02). Conclusion An ultra‐short bowel and alcohol consumption are independent risk factors for liver fibrosis in adults requiring HPN .