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Abnormalities in the 24‐hour rhythm of skin temperature in cirrhosis: Sleep‐wake and general clinical implications
Author(s) -
Garrido Maria,
Saccardo Desy,
De Rui Michele,
Vettore Elia,
Verardo Alberto,
Carraro Paolo,
Di Vitofrancesco Nicola,
Mani Ali R.,
Angeli Paolo,
Bolognesi Massimo,
Montagnese Sara
Publication year - 2017
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13525
Subject(s) - cirrhosis , medicine , morning , circadian rhythm , melatonin , sleep (system call) , gastroenterology , cardiology , computer science , operating system
Background & Aims Sleep preparation/onset are associated with peripheral vasodilatation and a decrease in body temperature. The hyperdynamic syndrome exhibited by patients with cirrhosis may impinge on sleep preparation, thus contributing to their difficulties falling asleep. The aim of this study was the assessment of skin temperature, in relation to sleep‐wake patterns, in patients with cirrhosis. Methods Fifty‐three subjects were initially recruited, and 46 completed the study. Of the final 46, 12 were outpatients with cirrhosis, 13 inpatients with cirrhosis, 11 inpatients without cirrhosis and 10 healthy volunteers. All underwent baseline sleep‐wake evaluation and blood sampling for inflammatory markers and morning melatonin levels. Distal/proximal skin temperature and their gradient ( DPG ) were recorded for 24 hours by a wireless device. Over this period subjects kept a sleep‐wake diary. Results Inpatients with cirrhosis slept significantly less well than the other groups. Inpatients and outpatients with cirrhosis had higher proximal temperature and blunted rhythmicity compared to the other groups. Inpatients with/without cirrhosis had higher distal temperature values and blunted rhythmicity compared to the other groups. Inpatients and outpatients with cirrhosis had significantly lower DPG values compared to the other groups, and DPG reached near‐zero values several hours later. Significant correlations were observed between temperature and sleep‐wake variables and inflammatory markers. Conclusions Alterations of distal/proximal skin temperature, their gradient and their time‐course were observed in patients with cirrhosis, which may contribute to their sleep disturbances.