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Whole liver engineering: A promising approach to develop functional liver surrogates
Author(s) -
Meng Fanwei,
Assiri Abdallah,
Dhar Dipok,
Broering Dieter
Publication year - 2017
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13444
Subject(s) - bioartificial liver device , economic shortage , liver transplantation , liver failure , medicine , regenerative medicine , liver tissue , intensive care medicine , computer science , transplantation , surgery , biology , stem cell , hepatocyte , biochemistry , linguistics , philosophy , genetics , government (linguistics) , in vitro
Liver donor shortage remains the biggest challenge for patients with end‐stage liver failures. While bioartificial liver devices have been developed as temporary supports for patients waiting for transplantation, their applications have been limited clinically. Whole liver engineering is a biological scaffold based regenerative medicine approach that holds promise for developing functional liver surrogates. Significant advancements have been made since the first report in 2010. This review focuses on the recent achievements of whole liver engineering studies.