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Percutaneous microwave ablation of exophytic tumours in hepatocellular carcinoma patients: Safe or not?
Author(s) -
Ding Jianmin,
Zhou Yan,
Wang Yandong,
Jing Xiang,
Wang Fengmei,
Wang Yijun
Publication year - 2017
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13426
Subject(s) - medicine , percutaneous , microwave ablation , hepatocellular carcinoma , radiology , ablation , surgery , ultrasound , complication
Abstract Background & Aims To explore the long‐term outcomes and safety of ultrasound‐guided percutaneous microwave ablation ( MWA ) of exophytic tumours in hepatocellular carcinoma ( HCC ) patients. Methods One hundred and thirty‐two patients with subcapsular HCC were enrolled in this retrospective study. These patients were divided into the exophytic group (n=71) and non‐exophytic group (n=61) according to the location of the tumour(s). A special technology of puncture and ablation was performed to treat the exophytic tumours. The local tumour progression ( LTP ), progression free survival ( PFS ) and overall survival ( OS ) were analysed using Kaplan‐Meier and Log‐rank tests. Results Sixty‐nine of 71 exophytic tumours and 60 of 61 subcapsular tumours were completely ablated. The complete ablation rates were 97.2% and 98.4% respectively. The follow‐up periods ranged from 6 to 62 months with a median of 31 months in the exophytic group, and ranged from 5 to 61 months, with a median of 27 months in the non‐exophytic group. The 1‐, 3‐ and 5‐year cumulative LTP rates were 2.4%, 12.3%, 18.4% and 5.1%, 12.0%, 17.8% in the exophytic and non‐exophytic groups respectively ( P =.733). The 1‐, 3‐ and 5‐year OS rates were 100%, 75.7%, 52.9% and 95.0%, 73.8%, 61.5% in the exophytic group and non‐exophytic group respectively ( P =.980). There was no procedure‐related mortality or major complication. Conclusion Ultrasound‐guided percutaneous MWA is safe and effective for exophytic tumours in HCC patients. Treated by MWA , the HCC patients with exophytic tumours can get the similar local response and long‐term outcome to those with non‐exophytic subcapsular tumours.