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Validating, deconstructing and refining Baveno criteria for ruling out high‐risk varices in patients with compensated cirrhosis
Author(s) -
Jangouk Parastoo,
Turco Laura,
De Oliveira Ana,
Schepis Filippo,
Villa Erica,
GarciaTsao Guadalupe
Publication year - 2017
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13379
Subject(s) - varices , medicine , cirrhosis , cohort , transient elastography , portal hypertension , retrospective cohort study , gastroenterology , esophageal varices , cohort study , liver fibrosis
Background Guidelines recommend variceal screening in patients with cirrhosis to identify varices at high risk of bleeding requiring primary prophylaxis. Non‐invasive criteria to rule out high‐risk varices will avoid unnecessary endoscopies. Recent Baveno VI criteria define patients with compensated cirrhosis in whom endoscopy can be avoided as those with a liver stiffness by transient elastography <20 kP a and a platelet count >150 000/mm 3.Aims To validate Baveno criteria in two cohorts with a different prevalence of high‐risk varices and to determine whether alternate parameters not including liver stiffness would be equal/more accurate in ruling out high‐risk varices. Methods Retrospective study evaluating patients with liver stiffness >10 kP a who had liver stiffness and endoscopy within 1 year of each other. Results This study included 161 patients from the US cohort (14 [9%] with high‐risk varices) and 101 patients from an Italian cohort (17 [17%] with high‐risk varices). Of patients meeting Baveno criteria (41 in the US , 16 in Italy), none had high‐risk varices and therefore 26% ( US ) and 16% (Italy) endoscopies could have been avoided. Sensitivity and negative predictive value were 100%. A stepwise strategy using platelet count >150 000 and MELD =6, increased the number of endoscopies avoided to 54% ( US ) while maintaining a sensitivity and negative predictive value of 100%. Excellent sensitivity and negative predictive value were validated in the Italian cohort and in another cohort of patients with a clinical diagnosis of cirrhosis. Conclusions This study validates Baveno VI criteria, particularly in sites with a low prevalence of high‐risk varices and describes a new accurate strategy that does not include liver stiffness.