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Sofosbuvir‐based regimens for the treatment of hepatitis C virus in patients who underwent lung transplant: case series and review of the literature
Author(s) -
D'Ambrosio Roberta,
Aghemo Alessio,
Rossetti Valeria,
Carrinola Rosaria,
Colombo Massimo
Publication year - 2016
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13203
Subject(s) - medicine , sofosbuvir , cirrhosis , hepatitis c virus , hepatitis c , lung , bone marrow suppression , surgery , gastroenterology , intensive care medicine , virus , immunology , ribavirin , toxicity
Background Chronic infection with HCV can rapidly progress to cirrhosis leading to increased mortality rates in immunosuppressed organ‐transplanted patients. In liver‐transplanted patients, the introduction of directly acting antivirals has modified HCV natural history by providing a safe and effective therapy for this group of patients. To date there are no data on safety and efficacy of IFN‐free regimens in HCV patients who received lung transplant (LuT). Methods We report three patients who have received anti‐HCV treatment after LuT with Sofosbuvir‐based regimens. Results All patients achieved a SVR, no unexpected safety signals were observed and no modifications in immunosuppressants were required. Conclusions Our report is the first to show that HCV patients who underwent LuT can be safely treated with IFN‐free regimens, thus opening the door for refined clinical management of this category of patients.