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The enteric microbiome in hepatobiliary health and disease
Author(s) -
Tabibian James H.,
Varghese Cyril,
LaRusso Nicholas F.,
O'Hara Steven P.
Publication year - 2016
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.13009
Subject(s) - microbiome , intestinal microbiome , disease , hepatobiliary disease , gut microbiome , liver disease , computational biology , medicine , biology , bioinformatics , gastroenterology
Increasing evidence points to the contribution of the intestinal microbiome as a potentially key determinant in the initiation and/or progression of hepatobiliary disease. While current understanding of this dynamic is incomplete, exciting insights are continually being made and more are expected given the developments in molecular and high‐throughput omics techniques. In this brief review, we provide a practical and updated synopsis of the interaction of the intestinal microbiome with the liver and its downstream impact on the initiation, progression and complications of hepatobiliary disease.