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The impact of non‐alcoholic fatty liver disease on incident type 2 diabetes mellitus in non‐overweight individuals
Author(s) -
Fukuda Takuya,
Hamaguchi Masahide,
Kojima Takao,
Hashimoto Yoshitaka,
Ohbora Akihiro,
Kato Takahiro,
Nakamura Naoto,
Fukui Michiaki
Publication year - 2016
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12912
Subject(s) - overweight , medicine , fatty liver , hazard ratio , population , type 2 diabetes , incidence (geometry) , obesity , gastroenterology , diabetes mellitus , disease , endocrinology , environmental health , confidence interval , physics , optics
Abstract Background & Aims The aim of this study was to evaluate the impact of non‐alcoholic fatty liver disease ( NAFLD ) on incident type 2 diabetes mellitus (T2 DM ) in non‐overweight individuals with NAFLD . Methods A population‐based retrospective cohort study of 4629 participants who were enrolled in a health check‐up programme for more than 10 years. A standardized questionnaire and abdominal ultrasonography were used to diagnose NAFLD . A cut‐off point of BMI 23 kg/m 2 was used to define overweight (≥23.0 kg/m 2 ) or non‐overweight (<23.0 kg/m 2 ). The primary outcome was incident T2 DM . Results Over a mean follow‐up of 12.8 years, 351 participants (7.6%) developed T2 DM . The incidence rate of T2 DM was 3.2% in the non‐overweight without NAFLD group, 14.4% in the non‐overweight with NAFLD group, 8.0% in the overweight without NAFLD group and 26.4% in the overweight with NAFLD group. The adjusted hazard ratios for incident T2 DM compared with the non‐overweight without NAFLD group were as follows: 3.59 (95% CI: 2.14–5.76) in the non‐overweight with NAFLD group, 1.99 (95% CI : 1.47–2.69) in the overweight without NAFLD group and 6.77 (95% CI : 5.17–8.91) in the overweight with NAFLD group. The adjusted hazard ratio in the non‐overweight with NAFLD group was significantly higher than that in the overweight without NAFLD group or that in the non‐overweight without NAFLD group. Conclusions Non‐overweight individuals with NAFLD had a high risk of incident T2 DM . Diagnosis of NAFLD is important in non‐overweight individuals, and therefore it might be necessary to follow their health conditions on a long‐term basis after detection of NAFLD .