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Increased risk of preterm birth in women with autoimmune hepatitis – a nationwide cohort study
Author(s) -
Stokkeland Knut,
Ludvigsson Jonas F.,
Hultcrantz Rolf,
Ekbom Anders,
Höijer Jonas,
Bottai Matteo,
Stephansson Olof
Publication year - 2016
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12901
Subject(s) - medicine , autoimmune hepatitis , obstetrics , pregnancy , caesarean section , gestational diabetes , population , relative risk , cohort study , pediatrics , hepatitis , confidence interval , gestation , genetics , environmental health , biology
Background & Aims The aim of our study was to investigate the risks of pregnancy and childbirth complications in women with autoimmune hepatitis compared to the population controls. Methods In a nationwide cohort study of all pregnancies between 2006 and 2011 we investigated the risks of adverse pregnancy outcome in 171 births in women with diagnosed autoimmune hepatitis using the data from the S wedish M edical B irth and P atient R egistries. Births to women without autoimmune hepatitis served as population controls ( n = 576 642). Relative risks ( RR ) with 95% confidence intervals ( CI ) were calculated using P oisson regression models adjusting for potential confounders. Results Women with AIH had an increased risk of gestational diabetes ( RR = 4.35, 95% CI 2.21–8.57), of preterm birth ( RR = 3.21, 95% CI 1.97–4.92) and of low‐birth‐weight child ( RR = 2.51, 95% CI 1.51–4.19). We found no statistically significant association between autoimmune hepatitis and pre‐eclampsia, caesarean section, low 5‐min Apgar score, small for gestational age birth, congenital malformation and neonatal mortality. Conclusions Autoimmune hepatitis is a risk factor for adverse pregnancy outcomes. High quality prenatal and antenatal care is important for women with autoimmune hepatitis and their infants.