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Birth order and risk of hepatocellular carcinoma in chronic carriers of hepatitis B virus: a case–control study in The Gambia
Author(s) -
Shimakawa Yusuke,
Lemoine Maud,
Bottomley Christian,
Njai Harr Freeya,
Ndow Gibril,
Jatta Abdoulie,
Tamba Saydiba,
Bojang Lamin,
Taal Makie,
Nyan Ousman,
D'Alessandro Umberto,
Njie Ramou,
Thursz Mark,
Hall Andrew J.
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12814
Subject(s) - medicine , hepatocellular carcinoma , hepatitis b virus , population , transmission (telecommunications) , odds ratio , hbsag , case control study , birth order , hepatitis b , obstetrics , pediatrics , immunology , virus , environmental health , electrical engineering , engineering
Background & Aims Early age at infection with Hepatitis B virus ( HBV ) increases the risk of chronic infection. Moreover, early HBV infection may further independently increase the risk of hepatocellular carcinoma ( HCC ) beyond its effect on chronicity. Methods The distribution of birth order, a proxy for mode and timing of HBV transmission, was compared in The Gambia between hepatitis B surface antigen ( HB sAg)‐positive HCC cases recruited from hospitals ( n = 72) and two HB sAg‐positive control groups without HCC : population‐based controls from a community HBV screening ( n = 392) and hospital‐based controls ( n = 63). Results HCC risk decreased with increasing birth order in the population‐based case – control analysis. Using first birth order as the reference, the odds ratios were 0.52 (95% CI : 0.20–1.36), 0.52 (0.17–1.56), 0.57 (0.16–2.05) and 0.14 (0.03–0.64) for second, third, fourth and greater than fourth birth order respectively ( P = 0.01). A similar inverse association was observed in the hospital‐based case – control comparison ( P = 0.04). Conclusions Compared to controls, HCC cases had earlier birth order, a proxy for young maternal age and maternal HBV viraemia at birth. This finding suggests that in chronic HBV carriers perinatal mother‐to‐infant transmission may increase HCC risk more than horizontal transmission. Providing HBV vaccine within 24 h of birth to interrupt perinatal transmission might reduce the incidence of HCC in The Gambia.