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TM 6 SF 2 E167K variant is associated with severe steatosis in chronic hepatitis C, regardless of PNPLA 3 polymorphism
Author(s) -
Coppola Nicola,
Rosa Zampino,
Cirillo Grazia,
Stanzione Maria,
Macera Margherita,
Boemio Adriana,
Grandone Anna,
Pisaturo Mariantonietta,
Marrone Aldo,
Adinolfi Luigi E.,
Sagnelli Evangelista,
Miraglia del Giudice Emanuele
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12781
Subject(s) - steatosis , medicine , gastroenterology , dyslipidemia , fibrosis , hepatitis c , fatty liver , cirrhosis , liver biopsy , triglyceride , biopsy , cholesterol , disease
Background & Aims A common non‐synonymous polymorphism, E167K, in transmembrane six superfamily member 2 ( TM 6 SF 2) gene has been recently associated with an increased hepatic triglyceride content, dyslipidemia and liver fibrosis in NAFLD patients. We investigated possible associations between the TM 6 SF 2 variants and liver lesions in chronic hepatitis C. Patients and Methods 148 consecutive patients with biopsy proven anti‐ HCV / HCV ‐ RNA ‐positive chronic hepatitis, naive for antiviral therapy, were genotyped for TM 6 SF 2 E167K and PNPLA 3 I148M variants. Results The score of liver steatosis was higher in the 18 patients with TM 6 SF 2 E167K variant (mean 1.9 ± 1.3) than in the 130 homozygotes for TM 6 SF 2 167E allele (1.1 ± 1.1, P  = 0.02), and the prevalence of a steatosis score ≥ 3 was 33.3% vs. 12.3% respectively ( P  = 0.02). No difference in necroinflammatory or fibrosis scores was found between the two groups. A general linear model identified as independent predictors of steatosis TM 6 SF 2 E167K and PNPLA 3 M148M variants and waist circumference ( P  = 0.0376, P  = 0.0069 and P  = 0.0273 respectively). Conclusions This is the first demonstration that TM 6 SF 2 E167K variant is an independent predictor of liver steatosis in chronic hepatitis C.

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