Premium
Prognostic role of magnetic resonance imaging vs. computed tomography for hepatocellular carcinoma undergoing chemoembolization
Author(s) -
Kim Beom Kyung,
Kim Kyung Ah,
An Chansik,
Yoo Eun Jin,
Park Jun Yong,
Kim Do Young,
Ahn Sang Hoon,
Han KwangHyub,
Kim Seung Up,
Kim MyeongJin
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12751
Subject(s) - medicine , magnetic resonance imaging , hepatocellular carcinoma , radiology , hyperintensity , nuclear medicine , diffusion mri , hazard ratio , imaging biomarker , gadoxetic acid , confidence interval , gadolinium dtpa
Background & Aims Computed tomography ( CT ) and magnetic resonance imaging ( MRI ) play important roles in diagnosis and staging of hepatocellular carcinoma ( HCC ). However, prognostic roles of radiological characteristics are not yet determined. Methods Eighty‐eight patients treated with chemoembolization were analysed. Radiological parameters at baseline were assessed in all patients using both dynamic CT and MRI . Treatment responses were assessed using modified RECIST 4 weeks after the first chemoembolization. Results Gross vascular invasion ( GVI ), bile duct invasion, irregular tumour margin ( ITM ), peripheral ragged enhancement ( PRE ) and satellite nodules on CT or MRI were associated with non‐response (stable disease or progression) after chemoembolization respectively (all P ≤ 0.05). GVI , ITM and PRE on CT or MRI were also independently associated with poor overall survival ( OS ) respectively (all P ≤ 0.05). Using these results, a prognostic scoring system for CT and MRI were developed; 0, absence of all three features ( GVI , ITM and PRE ); 1, presence of one feature; 2, presence of two features; and 3, presence of three features. After adjusting tumour size, tumour number and alpha‐foetoprotein level, both CT and MRI scores were independently associated with OS (both P < 0.001). Patients with CT or MRI score ≥2 had a worse OS than those with score <2 (adjusted hazard ratios, 3.837 and 2.938 respectively). MRI ‐specific parameters such as signal intensity on T2‐ or T1‐weighted images, fat signal or hyperintensity on diffusion‐weighted images did not have prognostic value (all P > 0.05). Conclusions Radiological parameters by CT and MRI may be useful in biological characterization of tumours and prognostification for HCC treated with chemoembolization.