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Prospective evaluation of PBC ‐specific health‐related quality of life questionnaires in patients with primary sclerosing cholangitis
Author(s) -
RaszejaWyszomirska Joanna,
Wunsch Ewa,
Krawczyk Marek,
Rigopoulou Eirini I,
Bogdanos Dimitrios,
Milkiewicz Piotr
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12730
Subject(s) - medicine , primary biliary cirrhosis , quality of life (healthcare) , primary sclerosing cholangitis , gastroenterology , cohort , cirrhosis , disease , liver disease , nursing
Background & Aims Primary biliary cirrhosis and Primary sclerosing cholangitis are autoimmune cholestatic liver diseases sharing a lot in common, including a significant impairment of patients’ health‐related quality of life HRQ oL HRQ oL in PBC is assessed with disease‐specific PBC ‐40 and PBC ‐27 questionnaires. A PSC ‐specific questionnaire has not been developed. Neither PBC ‐40 nor PBC ‐27s applicability for PSC has been evaluated. We applied these three questionnaires for HRQ oL assessment in a large homogenous cohort of PSC patients. Patients and Methods This cross‐sectional study enrolled 102 Caucasian PSC s and 53 matched healthy controls and measured HRQ oL using generic SF ‐36, and disease‐specific ( PBC ‐40/ PBC ‐27) questionnaires. Results (i) SF ‐36. Most SF ‐36 domains were significantly lower in PSC s than controls. Physical Functioning and Mental Component Summary scores were significantly lower in female patients and correlated negatively with age but not with concurrent inflammatory bowel disease. Cirrhosis was associated with lower Physical Functioning, Role Physical, General Health, Vitality and Physical Component Summary. (ii) PBC ‐40 and PBC ‐27. Both tools showed similar HRQ oL impairment scoring. Fatigue and Cognitive were impaired in female patients. Several correlations existed between HRQ oL and laboratory parameters, including cholestatic tests and Itch. Cirrhosis correlated with Other symptoms and Fatigue PBC ‐40. (iii) PBC ‐40 vs PBC ‐27. Strong correlations among most domains of both questionnaires were seen, as well as between (iv) SF ‐36 vs PBC ‐40 or SF ‐36 vs PBC ‐27. Conclusion This is the first study directly comparing PBC ‐40, PBC ‐27 and SF ‐36 in PSC . PSC patients, especially females, show HRQ oL impairment. PBC ‐40 and PBC ‐27 questionnaires could be of potential use for HRQ oL assessment in PSC .