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Optimal interferon‐free therapy in treatment‐experienced chronic hepatitis C patients
Author(s) -
Peter Joy,
Nelson David R.
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12718
Subject(s) - medicine , tolerability , chronic hepatitis , cirrhosis , dosing , interferon , intensive care medicine , hepatitis c , adverse effect , immunology , virus
Over the past year, interferon ( IFN ) free dosing regimens have become available to treat chronic hepatitis C. Offering high rates of sustained virological response ( SVR ), short treatment and improved tolerability, IFN ‐free treatment now represents the paradigm for both treatment‐naïve and ‐experienced patients. Patients with prior treatment failure, in particular those with cirrhosis, still represent some of the most difficult to treat, but the availability of multiple agents that can interrupt several steps of the HCV lifecycle affords providers and patients with options that can be combined and individually tailored to each patient's unique needs to obtain high rates of SVR .