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Interleukin‐28B genetic variants in untreated Italian HCV ‐infected patients: a multicentre study
Author(s) -
Mottola Leonardo,
Cenderello Giovanni,
Piazzolla Valeria A.,
Forte Paolo,
Carretta Vito,
Mecenate Fabrizio,
Brancaccio Giuseppina,
Minisini Rosalba,
Zuin Massimo,
Terreni Natalia,
Monti Monica,
Colombo Alberto Eraldo,
Nosotti Lorenzo,
Minerva Nicola,
Luzzitelli Ilaria,
Kostandini Alba,
Cuccorese Giuseppe,
Russello Maurizio,
Santoro Rosanna,
Mangia Alessandra
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12630
Subject(s) - genotype , medicine , gastroenterology , immunology , biology , gene , genetics
Background & Aims Different prevalence of favourable IL 28 BCC genotype have been reported in studies performed in different countries around the world. Data on distribution of IL 28B genotypes in healthy Italian subjects are lacking. Methods Studies on prospectively collected untreated chronic HCV ‐infected Italian patients led to conflicting results. To investigate the prevalence of IL 28B genotypes in untreated HCV ‐infected patients and in subjects able to clear HCV , and to compare them to the prevalence registered in healthy Italian controls. To evaluate IL 28B prevalence across different HCV genotypes. Results IL 28 BCC was observed in 30.9% of chronic HCV patients, in 71.0% of subjects able to clear HCV infection and in 41.6% of the Italian controls. The frequency of IL 28 BCC was higher in HCV genotype 2 and 3 than in 1 (38.3 vs. 28.2) ( P = 0.02). Levels of ALT higher in IL 28 BCC than in non‐ CC were observed regardless of HCV genotypes ( P = 0.0014). Conclusions IL 28 BCC frequencies progressively decline from subjects with spontaneous HCV clearance to normal non‐infected subjects and to chronically infected. This study suggests that patients with IL 28 BCC , if genotype 1, are able to clear HCV more often than if genotype 2 and 3 infected, and that CC genotype is associated with higher grade of necro‐inflammation.