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Interleukin‐28 gene polymorphisms may contribute to HB sAg persistence and the development of HB eAg‐negative chronic hepatitis B
Author(s) -
Karataylı Senem C.,
Bozdayı Mithat,
Karataylı Ersin,
Öztürk Tuğba,
Husseini Abbas A.,
Albayrak Rabia,
Özkan Muhip,
Kalaylıoğlu Zeynep,
Yalçın Kendal,
Çınar Kubilay,
İdilman Ramazan,
Yurdaydın Cihan
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12595
Subject(s) - genotype , persistence (discontinuity) , medicine , chronic hepatitis , genotyping , gastroenterology , single nucleotide polymorphism , cohort , immunology , hepatitis b , hepatitis b virus , gene , virology , biology , virus , genetics , geotechnical engineering , engineering
Abstract Background & Aims Aim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms ( SNP s) of the IL ‐28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HB sAg persistence. Further, a potential effect on the development of HB eAg‐negative CHB vs. inactive HB sAg carrier state was assessed in a genotype D HBV cohort. A cohort of chronic HDV patients was also used to see if they behave differently compared to chronic HBV patients. Methods This study was conducted in three main patient cohorts: Group 1 consisted of 482 patients with HB sAg persistence. Of them 143 were inactive carriers, 94 had HB eAg‐positive chronic hepatitis B ( CHB ) and 245 had anti‐ HB e‐positive CHB . Group 2 represents spontaneously recovered HBV patients; they were anti‐ HB s and anti‐ HB c positive. Group 3 consisted of 176 chronic hepatitis delta ( CHD ) patients with antidelta and HDV ‐ RNA positivity. DNA sequencing was performed for genotyping. Results When patients with HB sAg persistence were compared with spontaneously recovered patients, a significant difference was observed for rs8105790 ( P < 0.0001), rs12980275 ( P < 0.02). Patients who had the CC / TC genotype for rs8105790 ( P < 0.0001) and AA genotype for 1188122 ( P < 0.02) were more likely to be inactive HB sAg carriers, when inactive HB sAg carriers were compared with HB eAg‐negative CHB patients. Comparison of CHD patients vs. recovered HBV patients was parallel to that of HBV persistence vs. recovered HBV with similar significant differences in same SNP s. Conclusion These results suggest that IL ‐28B polymorphisms may contribute to HB sAg persistence and the development of the inactive HB sAg carrier state.