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Association of IL 28B polymorphisms with peginterferon treatment response in Chinese Han patients with HB eAg‐positive chronic hepatitis B
Author(s) -
Wu Haiqing,
Zhao Gangde,
Qian Fangxing,
Liu Kehui,
Xie Jingdong,
Zhou Huijuan,
Xu Jie,
Xu Yumin,
Han Yan,
Xie Qing,
Wang Hui
Publication year - 2015
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12491
Subject(s) - genotype , medicine , hepatitis b virus , hbeag , gastroenterology , immunology , hepatitis b , hbsag , virus , biology , gene , genetics
Aims To investigate whether IL 28B polymorphisms could affect the treatment response to peginterferon alpha ( PEG ‐ IFN ) in chronic hepatitis B ( CHB ) patients in the Chinese Han population. Methods A total of 212 hepatitis B e antigen (HBeAg)‐positive patients treated with PEG‐IFN monotherapy were enrolled in this study. Genotype analysis was performed for IL28B rs12980275, rs12979860 and rs8099917 using the MassArray system. Response was defined as cases showing normal aminotransferase (ALT) levels, HBV DNA level < 200 IU/ ml and HBeAg seroconversion after 48 weeks of PEG‐IFN therapy. Results The patients were infected with hepatitis B virus ( HBV ) genotype B (44.8%) and C (55.2%) with a total response rate of 34.9%. For the three SNP s, there were significant differences between the response (R) and non‐response ( NR ) groups both in allele frequencies and genotype distributions. IL 28B genotype was independently associated with R for AA vs. N‐ AA ( OR 2.70, 95% CL 1.21–6.01; P = 0.015) at rs12980275 after adjustment for sex, age, HBV genotype, baseline levels of HBV DNA and ALT . There were similar results for rs12979860 CC vs. N‐ CC ( OR 2.56, 95% CL 1.15–5.67; P = 0.021) and rs8099917 TT vs. N‐ TT ( OR 2.80, 95% CL 1.23–6.39; P = 0.015) respectively. Furthermore, one block formed by rs12980275 and rs12979860 was identified in this study. In multivariate analyses, the most common haplotype A‐C was independently associated with high rates of R ( OR 2.53, 95% CL 1.20–5.34; P = 0.015). Conclusions Our study suggested that genetic variations in IL 28B may play a critical role in PEG ‐ IFN efficacy in HB eAg‐positive CHB patients in Han Chinese.