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Histological subclassification of cirrhosis can predict recurrence after curative resection of hepatocellular carcinoma
Author(s) -
Kim Seung Up,
Jung Kyu Sik,
Lee Sarah,
Park Jun Yong,
Kim Do Young,
Ahn Sang Hoon,
Choi Gi Hong,
Kim Kyung Sik,
Choi Jin Sub,
Han KwangHyub,
Park Young Nyun
Publication year - 2014
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12475
Subject(s) - medicine , hepatocellular carcinoma , cirrhosis , hazard ratio , gastroenterology , stage (stratigraphy) , cumulative incidence , incidence (geometry) , hepatitis b virus , confidence interval , hepatitis b , carcinoma , multivariate analysis , surgery , virus , transplantation , paleontology , physics , virology , optics , biology
Background Recurrence of hepatocellular carcinoma ( HCC ) after curative resection continues to be a major cause of death. This prospective study is designed to investigate whether histological subclassification of cirrhosis using the Laennec system could predict recurrence in patients with hepatitis B virus ( HBV )‐related HCC after curative resection. Methods Patients with HBV ‐related HCC who underwent curative resection and showed Laennec stage 3 to 4 were enrolled and the cases with stage 4 were subclassified histologically into three groups (stages 4A, 4B and 4C) according to the Laennec system. Between February 2006 and August 2009, 92 patients were recruited. Results Stage 3, 4A, 4B and 4C were identified in 24 (26.1%), 15 (16.3%), 43 (46.7%) and 10 (10.9%) patients respectively. The cumulative incidence rates of recurrence at 1, 2 and 3 years were 24.2%, 40.5% and 55.1% respectively. On multivariate analysis, serum albumin [hazard ratio ( HR ), 0.528; 95% confidence interval ( CI ), 0.312–0.891; P = 0.017] and Edmondson–Steiner grade III – IV ( HR , 3.456; 95% CI , 1.123–10.517; P = 0.031) were significantly correlated with early recurrence (<1 year), whereas stage 4C ( HR , 5.426; 95% CI , 1.030–28.598; P = 0.046) was the only independent risk factor for late recurrence (≥1 year). Conclusions Histological subclassification of cirrhosis using the Laennec system is a significant predictor of late recurrence in patients with HBV ‐related HCC after curative resection.