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Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?
Author(s) -
Paridaens Annelies,
Laukens Debby,
Vandewynckel YvesPaul,
Coulon Stephanie,
Vlierberghe Hans,
Geerts Anja,
Colle Isabelle
Publication year - 2014
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12457
Subject(s) - endoplasmic reticulum , unfolded protein response , angiogenesis , signal transduction , microbiology and biotechnology , medicine , cancer research , biology
When cells are subjected to stress by changes in their extracellular environment, unfolded proteins accumulate in the endoplasmic reticulum ( ER ), causing ER stress. This initiates the unfolded protein response ( UPR ), a signal transduction cascade aiming at restoring cellular homeostasis. The UPR and angiogenesis are involved in the pathogenesis of many diseases such as cancer, pulmonary diseases and chronic liver diseases ( CLD s) including alcoholic liver disease, non‐alcoholic steatohepatitis and hepatitis B. This review summarizes the upcoming knowledge of the interaction between the UPR and angiogenesis in physiological angiogenesis and in different CLD s and other diseases.