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Genetic variation in interleukin 28B and correlation with chronic hepatitis B virus infection in Saudi Arabian patients
Author(s) -
AlQahtani Ahmed A.,
AlAnazi Mashael R.,
Abdo Ayman A.,
Sanai Faisal M.,
AlHamoudi Waleed K.,
Alswat Khalid A.,
AlAshgar Hamad I.,
Khalaf Nisreen Z.,
Viswan Nisha A.,
Al Ahdal Mohammed N.
Publication year - 2014
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12347
Subject(s) - interleukin 28b , medicine , single nucleotide polymorphism , cirrhosis , allele , hepatitis b virus , haplotype , hepatitis c virus , immunology , genetic variation , hepatitis , liver disease , snp , gastroenterology , virus , genotype , gene , biology , genetics , population , environmental health , ribavirin
Background & Aims Several genome‐wide association studies have shown that genetic variations in the chromosomal region containing interleukin‐28B ( IL 28B) gene are associated with response to treatment in hepatitis C virus ( HCV ) infection. This study was conducted to examine the role of genetic variations in IL 28B on disease progression in Saudi Arabian patients chronically infected with hepatitis B virus ( HBV ). Methods The study included 1128 subjects divided into four categories; 304 clearance subjects, 518 inactive carriers, 212 active carriers and 94 cirrhosis/ HCC . Results Three single nucleotide polymorphisms ( SNP s), rs12979860 ( OR = 1.307; 95% CI 1.046–1.634, χ 2 = 5.57 and P = 0.0183), rs12980275 ( OR = 0.642; CI 0.517–0.798, χ 2 = 16.17 and P = 0.0001) and rs8105790 ( OR = 0.746; CI 0.592–0.941, χ 2 = 6.12 and P = 0.0133), were found to be strongly associated with HBV clearance. The frequency of the G allele of rs12980275 and the C allele of rs8105790 were found to be more in clearance group than in patients and could contribute to protection against the disease. On the other hand, only rs12979860 showed significant difference in distribution when inactive group was compared to other groups ( OR = 1.285; CI 1.030–1.603, χ 2 = 4.95, P = 0.0261). No significant association was evident for any of the variants when active carriers were compared to cirrhosis/ HCC patients. Haplotype analysis showed that a combination of A‐T‐T‐G of rs12980275, rs8105790, rs8099917, and rs7248668, respectively, was associated with clearance of the virus (frequency = 67.5% and P = 0.015). Conclusion genetic variations in IL 28B gene region may influence the clearance of HBV infection.