Premium
Importance of screening for synchronous malignant neoplasms in patients with hepatocellular carcinoma: impact of FDG PET / CT
Author(s) -
Hiraoka Atsushi,
Hirooka Masashi,
Ochi Hironori,
Koizumi Yohei,
Shimizu Yuko,
Shiraishi Akiko,
Yamago Hiroka,
Tanihira Tetsuya,
Miyata Hideki,
Ninomiya Tomoyuki,
Kawasaki Hideki,
Ishimaru Yoshihiro,
Sogabe Ichiro,
Inoue Takeshi,
Abe Masanori,
Hiasa Yoichi,
Matsuura Bunzo,
Onji Morikazu,
Michitaka Kojiro
Publication year - 2013
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12161
Subject(s) - hepatocellular carcinoma , medicine , positron emission tomography , nuclear medicine , pet ct , radiology , carcinoma
Background & Aim Synchronous neoplasms ( SN s) are occasionally found in hepatocellular carcinoma ( HCC ). We examined such cases and the efficacy of 18‐fluoro‐2‐deoxyglucose positron‐emission tomography computed tomography ( PET / CT ), retrospectively. Materials and Methods We investigated 687 naïve HCC , who were admitted to our hospitals, encountered from O ctober 2006 to D ecember 2010 and evaluated the clinical backgrounds. All study protocols, was approved by our I nstitutional E thics C ommittee. The usefulness of detecting SN s by PET / CT was evaluated in 234 patients who underwent PET / CT ( PET group) and in 453 (non‐ PET group) examined in the same period. We noted the presence of SN s, defined as primary extrahepatic malignant neoplasms within 1 year of diagnosis of HCC . Results SN s were observed in 48 of 687 patients (54 tumours, 7.0%). SN s were detected by PET / CT in 18, which was 7.7% of PET group. The detection rate for SN s, were increased to 11.1% (26/234) in PET group by using together with upper gastrointestinal endoscopy and routine enhanced CT for HCC , which was greater than that of non‐ PET group (22/453, 4.9%) ( P < 0.001). Conclusion SN s were pointed out more frequently in PET group than non‐ PET group (11.1% vs. 4.9%). FDG PET / CT can enhance the detection ability for SN s in naïve HCC .