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Primary biliary cirrhosis does not increase the risk of UTI s following diagnosis compared to other chronic liver diseases?
Author(s) -
Varyani Fumi K.,
West Joe,
Card Timothy R.
Publication year - 2013
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12107
Subject(s) - medicine , hazard ratio , primary biliary cirrhosis , gastroenterology , population , confidence interval , proportional hazards model , diabetes mellitus , cirrhosis , cohort , urinary system , endocrinology , environmental health
Background Urinary Tract Infections ( UTI s) occur more frequently in patients with Primary Biliary Cirrhosis ( PBC ). Previous studies have compared UTI occurrence in PBC and general population controls, however, it remains unclear if UTI is a feature of all chronic liver diseases ( CLD )s, or is specific to PBC , or if this is a cause or consequence of PBC . Aims We aimed to determine if UTI s are more common after a diagnosis of PBC compared to general population and CLD controls. Methods A cohort study was conducted using the General Practice Research Database. We selected all cases of PBC plus 10 age‐ and sex‐matched general population controls, and an unmatched group with other CLD s. We formed a Cox–proportional hazard model of time to first UTI following diagnosis. Results Two hundred and forty‐eight (24.6%) of PBC cases had a UTI event compared with 2127 (21.1%) of matched and 2131 (11.7%) of the unmatched CLD controls. Comparing PBC with matched controls showed an approximately 30% increased risk of UTI [hazard ratio ( HR ) 1.33 confidence interval ( CI ) 1.17–1.52]. Adjusting for diabetes, smoking and previous UTI reduced this ( HR 1.25 CI 1.09–1.42). The Hazard Ratio comparing PBC with unmatched CLD controls was 2.00 ( CI 1.76–2.28), but this became non‐significant when adjusting for age, sex, diabetes, smoking and previous UTI 0.98 (0.86–1.12). Conclusions There is increased risk of UTI in PBC patients compared to general population controls, but not compared to CLD controls suggesting that this association is not specific to PBC after diagnosis.