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New therapeutic strategies in HCV: polymerase inhibitors
Author(s) -
Gerber Ludmila,
Welzel Tania M.,
Zeuzem Stefan
Publication year - 2013
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12068
Subject(s) - polymerase , virology , rna polymerase , medicine , biology , enzyme , rna , biochemistry , gene
The characterization of the viral life cycle facilitated the development of directly acting antiviral drugs. Among those, several inhibitors of the viral RNA‐dependent RNA polymerase have proven effectiveness in clinical trials. The characteristics of different nucleos(t)ide and non‐nucleoside polymerase inhibitors, as well as their clinical applications and combinations with other classes of directly acting antiviral drugs are reviewed herein.