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The performance of transient elastography compared to clinical acumen and routine tests – what is the incremental diagnostic value?
Author(s) -
Dolman Grace E.,
Nieboer Daan,
Steyerberg Ewout W.,
Harris Scott,
Ferguson Amanda,
Zaitoun Abed M.,
Ryder Stephen D.,
James Martin W.,
Aithal Guruprasad P.,
Guha Indra Neil
Publication year - 2013
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/liv.12017
Subject(s) - transient elastography , medicine , cirrhosis , elastography , receiver operating characteristic , fibrosis , liver fibrosis , area under the curve , diagnostic accuracy , clinical practice , predictive value of tests , radiology , retrospective cohort study , hepatic fibrosis , gastroenterology , ultrasound , physical therapy
Background/Aims There is substantial evidence suggesting transient elastography (TE) is a useful tool in assessing liver fibrosis. We aimed to determine whether TE has incremental diagnostic value over clinical acumen and routinely available tests. Methods We performed a retrospective study of 130 patients to assess the ability of hepatologists to predict severity of fibrosis using clinical acumen; clinical acumen with routine tests; and elastography in patients with chronic liver disease. The incremental diagnostic benefit was assessed using the area under the ROC curve ( AUC ) and the Net Reclassification Index ( NRI ). Results Using universally available tests, including clinical acumen, the AUC s for detection of cirrhosis ranged from 0.70 to 0.80 for the four hepatologists. Elastography led to statistically non‐significant improvements in AUC statistics (range 0.83–0.89; P > 0.01). The detection of significant fibrosis using clinical acumen and routine tests was less accurate, with AUC s of 0.52–0.59. Elastography had incremental diagnostic value ( AUC performance range 0.76–0.82; P < 0.01). The NRI indicated that 39–58% were correctly reclassified using elastography, especially with respect to sensitivity. Conclusions Our study suggests that the diagnostic value of clinical acumen and routine tests is acceptable for detection of cirrhosis, but not significant fibrosis. Elastography detects significant fibrosis or cirrhosis with acceptable accuracy and offered incremental diagnostic value in detecting significant fibrosis, but not cirrhosis. These findings have implications for determining the diagnostic value of tests over and above routine clinical assessment, which will aid incorporation of novel tests into clinical algorithms.