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Antimicrobial activity and toxicity of gold nanoparticles: research progress, challenges and prospects
Author(s) -
Tao C.
Publication year - 2018
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/lam.13082
Subject(s) - antimicrobial , colloidal gold , nanotechnology , nanoparticle , toxicity , antibiotics , chemistry , biochemical engineering , materials science , engineering , biochemistry , organic chemistry
Gold nanoparticles are emerging materials that exhibit characteristics distinct from those of traditional materials and that have promising potential for application in the fields of chemistry, physics, biology and medicine. During the past decades, numerous studies on the antimicrobial activity and toxicity of gold nanoparticles have been published. With respect to antimicrobial activity, gold nanoparticles conjugated with small molecules, such as antibiotics, drugs, vaccines and antibodies, are more efficient than individual nanoparticles and molecules. Regarding the toxicity effects, results are often unclear and conflicting because of the lack of a standard experimental method; various studies have used different approaches, administration routes and doses, and similar experiments may lead to different conclusions. To provide a systematic overview of and insight in the current knowledge for researchers committed to this filed, we discuss the recent research advances related to the antimicrobial activity and toxicity of gold nanoparticles, both in vitro and in vivo , and identify major issues that require further study. Significance and impact of the study This paper discusses the recent research progress on antimicrobial activity and toxicity of gold nanoparticles and provides general insights into the field for researchers committed to this field.