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Mycobactericidal activity of hydrogen peroxide activated by a novel heterogeneous F entons‐like catalyst system
Author(s) -
Price S.L.,
Huddersman K.D.,
Shen J.,
Walsh S.E.
Publication year - 2013
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/lam.12010
Subject(s) - hydrogen peroxide , polyacrylonitrile , catalysis , chemistry , peroxide , biocide , organic chemistry , polymer
To investigate the potential activation of hydrogen peroxide by a novel catalyst, reducing the concentration of hydrogen peroxide required and the time taken for mycobactericidal activity. The mycobactericidal properties of an iron‐based novel heterogeneous‐modified polyacrylonitrile ( PAN ) catalyst in combination with hydrogen peroxide were examined against Mycobacterium chelonae using a modified version of the European suspension test. Mycobactericidal activity was significantly increased when the modified PAN catalyst was combined with hydrogen peroxide. The 0·5% w/v hydrogen peroxide and 2‐g catalyst system resulted in average Log reductions of >5·80 for M yco. chelonae at 30‐min exposure at room temperature. This was a significant increase in activity ( P < 0·01) compared to 0·5% w/v hydrogen peroxide alone. This study has expanded on previous work and knowledge of the modified PAN catalyst and hydrogen peroxide system, by providing evidence for mycobactericidal activity when the novel PAN catalyst is combined with hydrogen peroxide. Significance and Impact of the Study This study expands on previous published work by demonstrating the enhanced mycobactericidal activity gained by using the novel heterogeneous polyacrylonitrile catalyst, developed at De Montfort University, to potentiate the activity of hydrogen peroxide as a biocide. The increased activation of hydrogen peroxide by this system enables lower concentrations, and shorter contact times, to be used. This system could be used as an alternative within the healthcare sector, such as endoscope disinfection.