Response to the Werner (2016) comment on ‘Polyploid unisexual salamanders have higher tissue regeneration rates than diploid sexual relatives’

In his comment on Saccucci et al. (2016), Yehudah Werner (2016) suggests that differences in regeneration rate between diploid and polyploid salamanders could simply be a result of differences in thermal optima for each group relative to the temperatures at which the experiments were conducted. While this is possible, I feel that this explanation is unlikely to account for the large difference observed in regeneration rates for the following three reasons.