Open AccessReplacing fish meal with cottonseed meal protein hydrolysate affects growth, intestinal function, and growth hormone/insulin‐like growth factor I axis of juvenile blunt snout bream ( Megalobrama amblycephala )
Author(s) -
Yuan XiangYang,
Jiang GuangZhen,
Cheng HuiHui,
Cao XiuFei,
Wang CongCong,
Dai YongJun,
Liu WenBin
Publication year - 2020
Publication title -
journal of the world aquaculture society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 60
eISSN - 1749-7345
pISSN - 0893-8849
DOI - 10.1111/jwas.12679
Subject(s) - biology , medicine , cottonseed meal , endocrinology , insulin like growth factor , growth hormone receptor , megalobrama , growth factor , soybean meal , hormone , growth hormone , biochemistry , receptor , raw material , ecology , gene
This study aimed to assess the effects of replacing fish meal with cottonseed meal protein hydrolysate (CPH) on the growth, intestinal function, growth hormone/insulin‐like growth factor I (GH/IGF‐I) axis, and inflammation of blunt snout bream, Megalobrama amblycephala . A total of 300 fish (38.66 ± 0.08 g) were allocated into five groups and fed either the basal diet (CPH 0) or the basal diet that replaced fish meal with 1% (CPH 1), 3% (CPH 3), 5% (CPH 5), and 7% CPH (CPH 7). Dietary CPH 3 increased the activities of protease, Na + /K + ‐ATPase, amylase, creatine kinase, and γ‐glutamyl transpeptidase; microvillus length in the anterior and mid intestines; and the mRNA levels of GH , growth hormone receptor ( GHR ), and IGF‐I without any negative effects on growth. Dietary CPH 7 increased the mRNA levels of tumor necrosis factor‐α, interleukin‐6, IκB kinase alpha, and nuclear factor κB but decreased the transcript level of inhibitor of κB‐α ( p < .05). Therefore, replacing fish meal with CPH 3 improved intestinal function and the transcription of GH/IGF‐I axis genes without any adverse effect on growth or triggering of inflammation in juvenile blunt snout bream.