Open AccessPharmacokinetics of Florfenicol in the Orange‐spotted Grouper, Epinephelus coioides , Following Oral Administration in Warm Seawater
Author(s) -
Feng JingBin,
Ruan HuiTing,
Chen HaiGang,
Luo JunZhi,
Dong JunDe
Publication year - 2018
Publication title -
journal of the world aquaculture society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 60
eISSN - 1749-7345
pISSN - 0893-8849
DOI - 10.1111/jwas.12509
Subject(s) - florfenicol , grouper , pharmacokinetics , biology , epinephelus , kidney , zoology , oral administration , medicine , endocrinology , fishery , pharmacology , biochemistry , fish <actinopterygii> , antibiotics
Pharmacokinetics of florfenicol were studied in the orange‐spotted grouper, Epinephelus coioides , at 29.0 ± 1.0 C following oral administration of 5 or 10 mg/kg. Rapid absorption occurred, with a T max (time to reach the maximum concentration) of 2–12 h in plasma, muscle, skin, liver, bile, intestine, kidney, and gill. The absorption rate appeared to decrease with increasing dosage, according to the observed T max in plasma, muscle, skin, liver, and kidney. The maximum concentration ( C max ) in plasma was 6.04 ± 1.11 and 13.01 ± 6.18 μg/mL at 5 and 10 mg/kg, respectively, and was lower than that in the intestine but higher than in the other six tissues. A similar absorption and availability was found between the two doses by comparison of the ratios of area under the concentration–time curve (AUC) and dose among the tissues. A relatively low distribution level occurred in extravascular tissues based on the AUC values, with the exception of bile and intestine. The shortest and longest elimination half‐life ( T 1/2β ) occurred in plasma (8.51 and 9.34 h at 5 and 10 mg/kg) and bile (18.13 and 17.63 h at 5 and 10 mg/kg), respectively. The elimination rate from plasma, muscle, and kidney was more rapid at 5 than at 10 mg/kg, according to the T 1/2β ; however, the opposite situation was observed in the remaining five tissues.