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Application of physiologically based pharmacokinetic models to promote the development of veterinary drugs with high efficacy and safety
Author(s) -
Zhou Kaixiang,
Mi Kun,
Ma Wenjin,
Xu Xiangyue,
Huo Meixia,
Algharib Samah Attia,
Pan Yuanhu,
Xie Shuyu,
Huang Lingli
Publication year - 2021
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12976
Subject(s) - physiologically based pharmacokinetic modelling , drug development , dosing , human health , pharmacokinetics , animal health , pharmacology , biochemical engineering , risk analysis (engineering) , medicine , microbiology and biotechnology , drug , biology , engineering , veterinary medicine , environmental health
Physiologically based pharmacokinetic (PBPK) models have become important tools for the development of novel human drugs. Food‐producing animals and pets comprise an important part of human life, and the development of veterinary drugs (VDs) has greatly impacted human health. Owing to increased affordability of and demand for drug development, VD manufacturing companies should have more PBPK models required to reduce drug production costs. So far, little attention has been paid on applying PBPK models for the development of VDs. This review begins with the development processes of VDs; then summarizes case studies of PBPK models in human or VD development; and analyzes the application, potential, and advantages of PBPK in VD development, including candidate screening, formulation optimization, food effects, target‐species safety, and dosing optimization. Then, the challenges of applying the PBPK model to VD development are discussed. Finally, future opportunities of PBPK models in designing dosing regimens for intracellular pathogenic infections and for efficient oral absorption of VDs are further forecasted. This review will be relevant to readers who are interested in using a PBPK model to develop new VDs.