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Determination of the route of excretion of robenacoxib (Onsior™) in cats and dogs: A pilot study
Author(s) -
King Jonathan N.,
Jung Martin
Publication year - 2021
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12973
Subject(s) - cats , beagle , urine , feces , excretion , medicine , crossover study , body weight , oral administration , physiology , pathology , biology , paleontology , alternative medicine , placebo
The objective of the studies was to determine the route of excretion, faecal or urinary, of the nonsteroidal anti‐inflammatory drug (NSAID) robenacoxib (Onsior™) in cats and dogs. The studies employed a two‐part crossover design in 4 beagle dogs (2 female and 2 male, age 36–41 months and body weight 9.0–10.3 kg) and a parallel group comparison of two groups each of 3 domestic short‐hair cats (2 female and 4 castrated male, age 35–73 months and body weight 3.0–5.7 kg). Animals were administered single doses of 1 (dog) or 2 (cat) mg/kg of [ 14 C]‐robenacoxib by intravenous (IV) and oral routes. Venous blood samples were taken and analysed for robenacoxib concentration. Faeces and urine were collected for 4 (cats) or 7 (dogs) days and analysed for radioactivity. Robenacoxib was eliminated rapidly from blood (≤ 8 hr). In dogs, expressed as the percentage of the administered dose and adjusted so that faecal plus urine recovery was 100%, the mean (SD) excretion in faeces and urine was, respectively, 64.6% (4.30) and 35.4% (4.3) after IV and 66.7% (6.9) and 33.3% (6.9) after oral administration. The respective values in cats, in faeces and urine, were 72.5% (4.6) and 27.5% (4.6) after IV and 78.5% (2.6) and 21.5% (2.6) after oral administration. In conclusion, excretion of systemically available robenacoxib in cats and dogs was mixed via both faeces and urine, but predominately faecal (~64.6% in dogs and ~72.5% in cats) and assumed to be via biliary excretion.