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Pharmacokinetics of single dose oral Terbinafine in common shelducks ( Tadorna tadorna )
Author(s) -
RojoSolís Carlos,
GarcíaPárraga Daniel,
Montesinos Andrés,
ArdiacaGarcía María,
Álvaro Teresa,
Valls Mónica,
BarrosGarcía Carlos,
Encinas Teresa
Publication year - 2021
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12942
Subject(s) - terbinafine , pharmacokinetics , pharmacology , oral administration , medicine , plasma concentration , adverse effect , toxicokinetics , antifungal , itraconazole , dermatology
Fungal disease is a major cause of morbidity and mortality in avian species; thus, antifungals are the treatment of choice. Despite widely used in clinical practice, terbinafine pharmacokinetic studies are scarce in literature and only cover some avian families, with marked differences between them. This study evaluates the pharmacokinetic behaviour of terbinafine after a single oral administration of 60 mg/kg in 7 healthy adult common shelducks ( Tadorna tadorna ) by measuring plasma concentrations through high‐performance liquid chromatography (HPLC) at times 0, 30 min, 1, 2, 4, 6, 8, 10, 12, 24, 36 and 48 hr postadministration. Noncompartmental analyses of the data showed a C max (geometric mean) of 5.43 µg/ml, t max (median) 1.0 hr and AUC 0‐∞ 29.70 mg h/L. Elimination half‐life was 6.33 hr and MRT 6.61 hr. Plasma concentrations remained above previously described MIC for terbinafine in some fungal species for at least 6 to 8 hr. A single oral administration of 60 mg/kg terbinafine did not produce adverse effects and could be a good treatment choice for fungal diseases in anatids.