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Effect of ketoprofen co‐administration on pharmacokinetics of cefquinome following repeated administration in goats
Author(s) -
Tekeli Ibrahim Ozan,
Turk Erdinc,
Durna Corum Duygu,
Corum Orhan,
Kirgiz Fatma Ceren,
Sakin Fatih,
Uney Kamil
Publication year - 2020
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12904
Subject(s) - ketoprofen , pharmacokinetics , volume of distribution , chemistry , pharmacology , crossover study , distribution (mathematics) , chromatography , medicine , alternative medicine , pathology , placebo , mathematical analysis , mathematics
The pharmacokinetics of cefquinome (2 mg/kg every 24 hr for 5 days) was determined following intramuscular administration alone and co‐administration with ketoprofen (3 mg/kg every 24 hr for 5 days) in goats. Six goats were used for the study. In the study, the crossover pharmacokinetics design with 20‐day washout period was performed in two periods. Plasma concentrations of cefquinome were assayed using high‐performance liquid chromatography by ultraviolet detection. The mean terminal elimination half‐life (t 1/2ʎz ), area under the concentration–time curve (AUC 0–24 ), peak concentration (C max ), apparent volume of distribution (V darea /F), and total body clearance (CL/F) of cefquinome after the administration alone were 4.85 hr, 11.06 hr*µg/ml, 2.37 µg/mL, 1.23 L/kg, and 0.17 L/h/kg after the first dose, and 5.88 hr, 17.01 hr*µg/mL, 3.04 µg/mL, 0.95 L/kg, and 0.11 L/h/kg after the last dose. Ketoprofen significantly prolonged t 1/2ʎz of cefquinome, increased AUC 0–24 and C max , and decreased V darea /F and CL/F. Cefquinome exhibited low accumulation after the administration alone and in combination with ketoprofen. These results indicated that ketoprofen prolonged the elimination of cefquinome in goats. The 24‐hr dosing intervals at 2 mg/kg dose of cefquinome, which co‐administered with ketoprofen, may maintain T> minimum inhibitory concentration (MIC) values above 40% in the treatment of infections caused by susceptible pathogens with the MIC value of ≤0.75 μg/ml in goats with an inflammatory condition.