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Effect of dose on the intravenous pharmacokinetics of tolfenamic acid in goats
Author(s) -
Tekeli Ibrahim Ozan,
Turk Erdinc,
Durna Corum Duygu,
Corum Orhan,
Kirgiz Fatma Ceren,
Uney Kamil
Publication year - 2020
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12898
Subject(s) - pharmacokinetics , volume of distribution , chemistry , washout , pharmacology , plasma concentration , zoology , medicine , biology
The objective of this study was to determine the pharmacokinetics of tolfenamic acid (TA) following intravenous (IV) administration at doses of 2 and 4 mg/kg in goats. In this study, six healthy goats were used. TA was administered intravenously to each goat at 2 and 4 mg/kg doses in a cross‐over pharmacokinetic design with a 15‐day washout period. Plasma concentrations of TA were analyzed using the high performance liquid chromatography with ultraviolet detector, and pharmacokinetic parameters were assigned by noncompartmental analysis. Following IV administration at dose of 2 mg/kg, area under the concentration–time curve (AUC 0−∞ ), elimination half‐life ( t 1/2ʎz ), total clearance (Cl T ) and volume of distribution at steady state ( V dss ) were 6.64 ± 0.81 hr * µg/ml, 1.57 ± 0.14 hr, 0.30 ± 0.04 L h ‐1 kg ‐1 and 0.40 ± 0.05 L/kg, respectively. After the administration of TA at a dose of 4 mg/kg showed prolonged t 1/2ʎz , increased dose‐normalized AUC 0‐∞ , and decreased Cl T . In goats, TA at 4 mg/kg dose can be administered wider dose intervals compared to the 2 mg/kg dose. However, further studies are needed to determine the effect of different doses on the clinical efficacy of TA in goats.