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The effect of breed, sex, and drug concentration on the pharmacokinetic profile of ivermectin in cattle
Author(s) -
Gotardo André Tadeu,
Fonseca Rafael Lanzelloti,
Barreto Fabiano,
Tomaszewski Caroline Andrade,
Barnet Lucas Suchecki,
Castilho Tamara,
Górniak Silvana Lima
Publication year - 2020
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12862
Subject(s) - ivermectin , pharmacokinetics , crossbreed , breed , anthelmintic , zoology , plasma concentration , veterinary medicine , biology , pharmacology , medicine
Ivermectin (IVM) is one of the most widely used antiparasitic drugs worldwide and has become the drug of choice for anthelmintic and tick treatment in beef cattle production. It is known that pharmacokinetic parameters are fundamental to the rational use of a drug and food safety and these parameters are influenced by different factors. The aim of this study was to evaluate the pharmacokinetic profile of IVM in Bos indicus , Bos taurus , and crossbreed cattle ( B. indicus × B. taurus ) kept under same field conditions and the possible impacts of sex and IVM formulation (1% and 3.15%). It was observed that IVM concentration was significantly affected by breed. The plasma concentrations of IVM, AUC, C max , and t 1/2β were significantly higher in B. indicus compared to B. taurus . Crossbreed animals showed an intermediate profile between European and Indian cattle. No alteration in pharmacokinetics parameters was detected when comparing different gender. Concerning the pharmacokinetic data of IVM formulation, it was verified that T max , AUC, and t 1/2β were higher in 3.15% IVM animals than those from 1% IVM formulation. The results clearly indicated that the IVM plasma concentrations in B. indicus were higher than that in B. taurus .