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Disposition of cyadox in domesticated cats following oral, intramuscular, and intravenous administration
Author(s) -
Sattar Adeel,
Hafeez Mian Abdul,
Wu Qin,
Tahir Adnan Hassan,
Shabbir Muhammad Abu Bakr,
Chen Dongmei,
Huang Lingli,
Xie Shuyu,
Yuan Zonghui
Publication year - 2020
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12836
Subject(s) - bioavailability , pharmacokinetics , cats , glucuronidation , pharmacology , metabolite , feces , oral administration , urine , beagle , first pass effect , chemistry , high performance liquid chromatography , crossover study , oral route , route of administration , intramuscular injection , medicine , chromatography , anesthesia , biology , biochemistry , paleontology , placebo , alternative medicine , pathology , enzyme , microsome
Cyadox (CYX) is a synthetic antibacterial agent of quinoxaline with much lower toxic effects. A safety criterion of CYX for clinical use was established by studying the pharmacokinetics and metabolism of CYX after oral (PO), intramuscular (IM), and intravenous (IV) administration. CYX was administered in six domesticated cats (three males and three females) by PO (40 mg/kg.b.w.), IM (10 mg/kg.b.w.), and IV (10 mg/kg.b.w.) routes in a crossover pattern. Highly sensitive liquid chromatography with ultraviolet detection (HPLC‐UV) method was developed for detection of CYX and its metabolites present in plasma, urine, and feces. The bioavailability of CYX after PO and IM routes was 4.37% and 84.4%. The area under curves (AUC), mean resident time (MRT), and clearance (CL) of CYX and its metabolites revealed that CYX quickly metabolized into its metabolites. The total recovery of CYX and its main metabolites was >60% after each route. PO delivery suggesting first pass effect in cats that might make this route suitable for intestinal infection and IM injection could be better choice for systemic infections. Less ability of glucuronidation did not show any impact on CYX metabolism. The findings of present study provide detailed information for evaluation of CYX.