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Pharmacokinetics and bioavailability of carbetocin after intravenous and intramuscular administration in cows and gilts
Author(s) -
Sun Pan,
Xiao Hongzhi,
Wang Jianzhong,
Zhang Suxia,
Cao Xingyuan
Publication year - 2020
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12830
Subject(s) - bioavailability , pharmacokinetics , medicine , route of administration , pharmacology , zoology , biology
The pharmacokinetics of carbetocin, which is used to control postpartum hemorrhage after giving birth, was studied in cows and gilts after a single intravenous (IV) or intramuscular (IM) injection. Blood samples from animals were assessed by oxytocin radioimmunoassay, and then the pharmacokinetic parameters were calculated using a noncompartmental model. For gilts, there was no significant difference between half‐life ( T 1/2λZ ), mean residue time (MRT), and maximum concentration ( C max ) between IM and IV administration. Conversely, the time to reach the C max ( T max ) and MRT were higher following administration of 350 μg/animal in cows via the IM administration compared with IV. The longest T 1/2λZ was 0.85 hr, indicating carbetocin was absorbed and eliminated rapidly in both animal species after administration. The T max was similar between cows and gilts following IM administration. Moreover, the C max after IM injection was about half that of IV administration in both animals. The bioavailability was more than 80% in cows, suggesting administration via the IM route is efficient. This is in agreement with the longer T 1/2λZ in cows after IM administration. However, the IV route is recommended for gilts due to a lower bioavailability (35%) and shorter T 1/2λZ after IM administration compared with IV.