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Pharmacokinetics of injectable marbofloxacin after intravenous and intramuscular administration in red‐eared sliders ( Trachemys scripta elegans )
Author(s) -
Lai Olimpia R.,
Marín Pedro,
Laricchiuta Pietro,
Gelli Donatella,
Escudero Elisa,
Crescenzo Giuseppe
Publication year - 2020
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12803
Subject(s) - pharmacokinetics , bioavailability , volume of distribution , pharmacology , forelimb , hindlimb , chemistry , medicine , zoology , biology , anatomy
Fluoroquinolone antibacterial drugs are currently used in reptilian medicine because of their broad spectrum of activity including the most frequent pathogens of these species. The disposition kinetics of marbofloxacin (MBX) at a single dose of 2 mg/kg were determined in healthy red‐eared sliders after intravenous (IV) and intramuscular (IM) administration. The influence of renal portal system on the bioavailability of the drug was investigated by using forelimb and hindlimb as IM injection sites. Apparent volume of distribution at steady‐state ( V ss ) and systemic clearance (Cl) of marbofloxacin after IV administration were estimated to be 48.21 ± 5.42 ml/kg and 23.38 ± 2.90 ml/hr·kg, respectively. The absolute bioavailabilities after IM route were 45.96% (forelimb) and 52.09% (hindlimb). The lack of statistically significant differences in most of the pharmacokinetic parameters after the two IM injection sites suggests a negligible influence of renal portal system in clinical use of MBX, although the C max after IM fore administration is advantageous, having into account the concentration‐dependent action of this antibiotic. The absence of visible adverse reactions in the animals and the advantageous pharmacokinetic properties suggest the possibility of its safe and effective clinical use in red‐eared sliders.