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Pharmacokinetics of altrenogest in gilts
Author(s) -
Xiao Hongzhi,
Sun Pan,
Sun Feifei,
Qiu Jicheng,
Wang Jie,
Wang Jianzhong,
Lin Yalong,
Gong Xiaohui,
Zhang Lu,
Zhang Suxia,
Cao Xingyuan
Publication year - 2019
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12755
Subject(s) - pharmacokinetics , zoology , plasma concentration , estrous cycle , chemistry , endocrinology , medicine , biology
Altrenogest, a synthetic progestogen, is characterized by its estrus synchronization in mares, ewes, sows, and gilts. To investigate the pharmacokinetic profile and evaluate its accumulation in gilts, 18 oral doses of 20 mg altrenogest/gilt/day were given to eight healthy gilts at an interval of 24 hr. Plasma samples were collected, and altrenogest was determined by ultra‐high‐performance liquid chromatography with mass spectrometry. WinNonlin 6.4 software was used to calculate the pharmacokinetic parameters through noncompartmental model analysis. After the first administration (D 1), the pharmacokinetic parameters, including T max , C max , and the elimination half‐life ( T 1/2λ z ), were similar to those observed after the final administration (D 18). However, the mean residence time at D 1 was significantly lower than D 18. As a whole, the mean steady‐state plasma concentration ( C ss ), degree fluctuation (DF), accumulation factor ( R ac ), and area under the plasma concentration–time curve in steady state ( AUC ss ) were 22.69 ± 6.15 ng/ml, 270.64 ± 42.51%, 1.53 ± 0.23, and 544.63 ± 147.49 ng hr/ml, respectively. These results showed that after 18 consecutive days of oral administration of altrenogest, plasma concentrations of altrenogest had a certain degree of fluctuation, without significant accumulations.