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Pharmacokinetics and bioavailability of danofloxacin in chukar partridge ( Alectoris chukar ) following intravenous, intramuscular, subcutaneous, and oral administrations
Author(s) -
Corum Orhan,
Durna Corum Duygu,
Atik Orkun,
Eser Faki Hatice,
Altan Feray,
Uney Kamil
Publication year - 2019
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12737
Subject(s) - danofloxacin , bioavailability , pharmacokinetics , crossover study , volume of distribution , zoology , medicine , veterinary medicine , pharmacology , chemistry , antibiotics , biology , enrofloxacin , placebo , biochemistry , alternative medicine , pathology , ciprofloxacin
The aim of the present study was to determine the pharmacokinetics ( PK s) and bioavailability of danofloxacin in chukar partridge ( Alectoris chukar ) following intravenous ( IV ), intramuscular ( IM ), subcutaneous ( SC ), and oral ( PO ) administrations at a dose of 10 mg/kg. A total of eight clinically healthy chukar partridges weighing 480 ± 45 g were used for the investigation. The study was performed in a crossover design (2 × 2 × 2 × 2) with a 15‐day washout period between two administrations in four periods. The plasma concentrations of danofloxacin were determined using reversed‐phase high‐performance liquid chromatography. Noncompartmental PK parameters were also estimated. No local or systemic adverse drug effects were observed in any of the chukar partridges. The mean elimination half‐life ranged between 8.18 and 12.08 hr and differed statistically among administration routes. The mean peak plasma concentrations of danofloxacin following IM , SC , and PO administrations were 8.05, 9.58, and 3.39 μg/ ml at 0.5, 1, and 4 hr, respectively. Following IM , SC , and PO administrations, the mean bioavailability was 86.33%, 134.40%, and 47.62%, respectively. The mean total clearance and volume of distribution at steady‐state following IV administration were 0.13 L hr −1 kg −1 and 0.96 L/kg, respectively. These data, including favorable PK s and the absence of adverse drug effects, suggest that danofloxacin is a useful antibiotic in chukar partridges.