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Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration
Author(s) -
Hu NanXi,
Chen Mei,
Liu YiSong,
Shi Qi,
Yang Bo,
Zhang HuanCheng,
Cheng Pi,
Tang Qi,
Liu ZhaoYing,
Zeng JianGuo
Publication year - 2019
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12729
Subject(s) - pharmacokinetics , sanguinarine , bioavailability , broiler , absorption (acoustics) , pharmacology , oral administration , chelerythrine , plasma concentration , chemistry , medicine , alkaloid , food science , biochemistry , physics , protein kinase c , acoustics , stereochemistry , enzyme
Sanguinarine ( SA ) and chelerythrine ( CHE ) are the main active components of the phytogenic livestock feed additive, Sangrovit®. However, little information is available on the pharmacokinetics of Sangrovit® in poultry. The goal of this work was to study the pharmacokinetics of SA , CHE , and their metabolites, dihydrosanguinarine ( DHSA ) and dihydrochelerythrine ( DHCHE ), in 10 healthy female broiler chickens following oral (p.o.) administration of Sangrovit® and intravenous (i.v.) administration of a mixture of SA and CHE . The plasma samples were processed using two different simple protein precipitation methods because the parent drugs and metabolites are stable under different pH conditions. The absorption and metabolism of SA following p.o. administration were fast, with half‐life ( t 1/2 ) values of 1.05 ± 0.18 hr and 0.83 ± 0.10 hr for SA and DHSA , respectively. The maximum concentration ( C max ) of DHSA (2.49 ± 1.4 μg/L) was higher that of SA (1.89 ± 0.8 μg/L). The area under the concentration vs. time curve ( AUC ) values for SA and DHSA were 9.92 ± 5.4 and 6.08 ± 3.49 ng/ml hr, respectively. Following i.v. administration, the clearance ( CL ) of SA was 6.79 ± 0.63 (L·h −1 ·kg −1 ) with a t 1/2 of 0.34 ± 0.13 hr. The AUC values for DHSA and DHCHE were 7.48 ± 1.05 and 0.52 ± 0.09 (ng/ml hr), respectively. These data suggested that Sangrovit® had low absorption and bioavailability in broiler chickens. The work reported here provides useful information on the pharmacokinetic behavior of Sangrovit® after p.o. and i.v. administration in broiler chickens, which is important for the evaluation of its use in poultry.