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Pharmacokinetic/pharmacodynamic integration of cefquinome against Pasteurella Multocida in a piglet tissue cage model
Author(s) -
Zhang Longfei,
Wu Xun,
Huang Zilong,
Kang Zheng,
Chen Yuqin,
Shen Xiangguang,
Cai Qinren,
Ding Huanzhong
Publication year - 2019
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12705
Subject(s) - pasteurella multocida , pharmacokinetics , pharmacodynamics , antibiotics , minimum inhibitory concentration , population , withdrawal time , pharmacology , microbiology and biotechnology , chemistry , medicine , biology , bacteria , genetics , colorectal cancer , environmental health , colonoscopy , cancer
To explore the in vivo antimicrobial activity of cefquinome against Pasteurella multocida in piglets, a piglet tissue cage infection model was used in this study. After the population of P. multocida reached 10 7 CFU/mL in a tissue cage, piglets received an intramuscular administration of cefquinome at 0.2, 0.4, 0.8, 1, 2, and 4 mg/kg once daily for 3 days. To assess the tissue cage pharmacokinetics ( PKTCF ) of cefquinome, tissue cage fluid was collected for cefquinome analysis at 1, 3, 6, 9, 12, and 24 hr after each of the 3 daily drug administrations. Bacteria were counted every 24 hr after drug administration and at 48 and 72 hr after the last administration. Evaluation of the relationship between pharmacokinetic/pharmacodynamic ( PK / PD ) parameters and the antibacterial effect showed that the surrogate of % T > minimum inhibitory concentration ( MIC ) ( R 2 = 0.981) was the best PK / PD index that correlated with effectiveness of cefquinome against P. multocida . The respective values of % T > MIC required for continuous 1/3‐log, 1/2‐log, and 1‐log reductions were 14.23, 34.45, and 73.44%, respectively, during each 24‐hr treatment period. In conclusion, cefquinome exhibited a potent antibacterial effect against P. multocida . When % T > MIC reached 73.44%, cefquinome exhibited a bactericidal effect against P. multocida after three successive daily administrations.