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The pharmacokinetics of moxidectin following intravenous and topical administration to swine
Author(s) -
Xiao Hongzhi,
Peng Haoyuan,
Zhao Ting,
kong Jingyuan,
Xue Jiao,
Wang Jianzhong,
Lin Yalong,
zhang Suxia,
Cao Xingyuan
Publication year - 2019
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12693
Subject(s) - pharmacokinetics , bioavailability , moxidectin , chemistry , volume of distribution , plasma concentration , pharmacology , clearance , zoology , half life , body weight , medicine , ivermectin , urology , veterinary medicine , biology
The pharmacokinetic parameters of moxidectin ( MXD ) after intravenous and pour‐on (topical) administration were studied in sixteen pigs at a single dose of 1.25 and 2.5 mg/kg BW (body weight), respectively. Blood samples were collected at pretreatment time (0 hr) over 40 days. The plasma kinetics were analyzed by WinNonlin 6.3 software through a noncompartmental model. For intravenous administration ( n = 8), the elimination half‐life (λ Z ), the apparent volume of distribution (V z ), and clearance (Cl) were 10.29 ± 1.90 days, 89.575 ± 29.856 L/kg, and 5.699 ± 2.374 L/kg, respectively. For pour‐on administration ( n = 8), the maximum plasma drug concentration ( C max ), time to maximum plasma concentration ( T max ), and λ Z were 7.49 ng/ml, 1.72, and 6.20 days, respectively. MXD had a considerably low absolute pour‐on bioavailability of 9.2%, but the mean residence time ( MRT ) for pour‐on administration 10.88 ± 1.75 days was longer than 8.99 ± 2.48 days for intravenous administration. These results showed that MXD was absorbed via skin rapidly and eliminated slowly. The obtained data might contribute to refine the dosage regime for topical MXD administration.