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Bayesian population pharmacokinetic modeling of florfenicol in pigs after intravenous and intramuscular administration
Author(s) -
Liu Zhichang,
Rong Ting,
Zeng Dongping,
Shen Xiangguang,
Ma Xianyong,
Zeng Zhenling
Publication year - 2018
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12677
Subject(s) - florfenicol , pharmacokinetics , population pharmacokinetics , medicine , bayesian probability , population , intramuscular injection , anesthesia , pharmacology , biology , mathematics , statistics , antibiotics , environmental health , microbiology and biotechnology
Bayesian population pharmacokinetic models of florfenicol in healthy pigs were developed based on retrospective data in pigs either via intravenous (i.v.) or intramuscular (i.m.) administration. Following i.v. administration, the disposition of florfenicol was best described by a two‐compartment open model with the typical values of half‐life at α phase ( t 1/2α ), half‐life at β phase ( t 1/2β ), total body clearance (Cl), and volume of distribution ( V d ) were 0.132 ± 0.0289, 2.78 ± 0.166 hr, 0.215 ± 0.0102, and 0.841 ± 0.0289 L kg −1 , respectively. The disposition of florfenicol after i.m. administration was best described by a one‐compartment open model. The typical values of maximum concentration of drug in serum ( C max ), elimination half‐life ( t 1/2Kel ), Cl, and Volume ( V ) were 5.52 ± 0.605 μg/ml, 9.96 ± 1.12 hr, 0.228 ± 0.0154 L hr −1 kg −1 , and 3.28 ± 0.402 L/kg, respectively. The between‐subject variabilities of all the parameters after i.m. administration were between 25.1%–92.1%. Florfenicol was well absorbed (94.1%) after i.m. administration. According to Monte Carlo simulation, 8.5 and 6 mg/kg were adequate to exert 90% bactericidal effect against Actinobacillus pleuropneumoniae after i.v. and i.m. administration.